• Users Online: 146
  • Print this page
  • Email this page
Year : 2022  |  Volume : 8  |  Issue : 3  |  Page : 78-82

Association of serum pleiotrophin levels with acute coronary syndrome

1 Department of Cardiology, Ankara City Hospital, Ankara, Turkey
2 Department of Cardiology, Yozgat City Hospital, Yozgat, Turkey

Correspondence Address:
Dr. Funda Basyigit
Bilkent Boulevard, Number: 1, 06800, Çankaya, Ankara
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijca.ijca_11_22

Rights and Permissions

Background and Aim: Pleiotrophin (PTN) is known as a multifunctional cytokine and a neurite outgrowth-promoting factor and appears as an angiogenic response to numerous processes such as ischemic injury affecting a region of the heart and the brain. We evaluated the serum concentration of PTN in clients with acute coronary syndrome (ACS), besides assessing the clients with no visible stenosis (NVS) in elective invasive coronary angiography (ICA). Materials and Methods: Through conducting a prospective research, we compared 110 consecutive patients with ACS referred for ICA with 47 stable patients with NVS. Results: We determined that ACS group had higher PTN levels than NVS group (244.94 ± 89.09 vs. 199.46 ± 70.71, P < 0.001). Based on the multivariate analysis, besides older age, smoking, and white blood cell, PTN ≥207.66 ng/ml remained independently associated with ACS. Conclusion: The serum concentration of PTN in clients was determined to have an association with ACS. The potential diagnostic and prognostic impact of PTN in ischemic heart disease may deserve to be further evaluated. PTN may also be studied as an angiogenic therapeutic factor in patients with ACS in additional studies.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded43    
    Comments [Add]    

Recommend this journal