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Year : 2022  |  Volume : 8  |  Issue : 1  |  Page : 8-13

Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease

Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India

Correspondence Address:
Dr. Nitin Tyagi
Department of Biochemistry, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi - 110 029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijca.ijca_47_21

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Objectives: This study aimed to determine the association of interleukin (IL)-10 and adiponectin (Ad) levels with the angiographic severity of coronary artery disease (CAD). Methods: In this case–control study, the study population included 50 patients with angiographically proven CAD as the case group and 50 apparently healthy age and sex-matched adults as a control group. The severity of CAD was assessed by SYNTAX scores. Serum Ad levels and IL-10 were measured using ELISA-based kits. The levels of Ad and IL-10 were associated with angiographic severity of CAD. P < 0.05 was considered statistically significant. Results: Cases had significantly lower Ad level (1.89 ± 1.18 vs. 2.59 ± 1.48, P = 0.0003) and significantly higher IL-10 level (8.96 ± 6.84 vs. 3.5 ± 3.57, P < 0.0001) as compared to controls. There was a significant correlation between the levels of Ad and IL-10 (r = 0.315, P = 0.026). There was a significant negative correlation between the Ad and angiographic stenosis of CAD (r = ‒0.939, P < 0.001). Both Ad and IL-10 showed a significant association with the severity of CAD in terms of SYNTAX score. Conclusion: Patients with CAD had lower Ad levels and higher IL-10 levels. Ad levels showed a significant decrease with increasing coronary artery stenosis. Both the markers (Ad and IL-10) showed significant association with the severity of CAD, thereby signifying their role as a marker for CAD.

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