• Users Online: 138
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2022  |  Volume : 8  |  Issue : 1  |  Page : 8-13

Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease


Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India

Correspondence Address:
Dr. Nitin Tyagi
Department of Biochemistry, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi - 110 029
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijca.ijca_47_21

Rights and Permissions

Objectives: This study aimed to determine the association of interleukin (IL)-10 and adiponectin (Ad) levels with the angiographic severity of coronary artery disease (CAD). Methods: In this case–control study, the study population included 50 patients with angiographically proven CAD as the case group and 50 apparently healthy age and sex-matched adults as a control group. The severity of CAD was assessed by SYNTAX scores. Serum Ad levels and IL-10 were measured using ELISA-based kits. The levels of Ad and IL-10 were associated with angiographic severity of CAD. P < 0.05 was considered statistically significant. Results: Cases had significantly lower Ad level (1.89 ± 1.18 vs. 2.59 ± 1.48, P = 0.0003) and significantly higher IL-10 level (8.96 ± 6.84 vs. 3.5 ± 3.57, P < 0.0001) as compared to controls. There was a significant correlation between the levels of Ad and IL-10 (r = 0.315, P = 0.026). There was a significant negative correlation between the Ad and angiographic stenosis of CAD (r = ‒0.939, P < 0.001). Both Ad and IL-10 showed a significant association with the severity of CAD in terms of SYNTAX score. Conclusion: Patients with CAD had lower Ad levels and higher IL-10 levels. Ad levels showed a significant decrease with increasing coronary artery stenosis. Both the markers (Ad and IL-10) showed significant association with the severity of CAD, thereby signifying their role as a marker for CAD.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1988    
    Printed142    
    Emailed0    
    PDF Downloaded173    
    Comments [Add]    

Recommend this journal